BCM-95® (CURCUGREEN®), 20 Mar 2015
Published on : Eur Neuropsychopharmacol . 2015 Jan;25(1):38-50. doi: 10.1016/j.euroneuro.2014.11.015. Epub 2014 Dec 5.

Curcumin in major depression & Peripheral biomarkers

Adrian L Lopresti 1, Michael Maes 2, Marc J M Meddens 3, Garth L Maker 4, Eddy Arnoldussen 3, Peter D Drummond 5

PMID: 25523883 DOI: 10.1016/j.euroneuro.2014.11.015

Curcumin and major depression: A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change

Adrian L. Loprestia, Michael Maesb, Marc J.M. Meddensd, Garth L. Makere, Eddy Arnoldussend, Peter D. Drummonda


Abstract: A recent randomised, double-blind, placebo controlled study conducted by our research group, provided partial support for the efficacy of supplementation with a patented curcumin extract (500 mg, twice daily) for 8 weeks in reducing depressive symptoms in people with major depressive disorder.

Procedure: Participants were randomly and equally allocated into two groups (placebo and curcumin) using a randomisation calculator. Both curcumin and placebo capsules were packed in identical containers labelled by participant code numbers and allocation was assigned by the first author according to order of participant enrolment in the study. As no previous clinical study has investigated the effect of curcumin on most of the measured biomarkers, data to complete an a priori power analysis could not be determined. However, to achieve a power of 0.8, sample size estimates were based on the assumption of a moderate effect size of 0.4 indicating a total sample size of approximately 50 was required for this study.

Results: Univariate tests exploring the effects of the group by time on the different individual urinary biomarkers revealed significant group time interactions.

Conclusion: Important preliminary findings were identified as Urinary cortisol levels trended downward following placebo treatment and trended upward following curcumin treatment, resulting in significant between-group differences. Determining reasons for these differences are difficult as they were not related to treatment outcome. Speculatively, curcumin may have enhanced endothelin or leptin receptor sensitivity or some other mechanism associated with biomarkers which, in turn, had antidepressant effects.

Limitations: The relatively small samples size and the large number of statistical analyses used in this study limits the reliability and statistical power associated with the findings.


  • antidepressant
  • bcm
  • BCM-95
  • bcm95
  • clinical study
  • curcugreen
  • Curcumin
  • research
  • turmeric
  • turmeric extract


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