Library
BCM-95® (CURCUGREEN®), 23 Mar 2013
Published on : Published 2013 Chemistry
EVALUATION OF ANTIEPILEPTIC AND MEMORY RETENTION ACTIVITY OF CURCUMIN PER SE AND IN COMBINATION WITH ANTIEPILEPTIC DRUGS.
Ashish P. Anovadiya, J. Sanmukhani, Vishal K. Vadgama, C. Tripathi
Corpus ID: 53392015
Antiepileptic activity of curcumin and its combination with phenytoin and sodium valproate were studied in chronic model (14 days) of Maximal Electroshock Seizure (MES) and Pentylenetetrazole (PTZ) induced seizure respectively. Elevated plus maze test was used to study effect of drugs and/or seizures on memory retention in MES and PTZ groups. Curcumin in both doses did not show any significant effect (P = 0.33) on tonic extension, while curcumin 100 mg/kg significantly (P < 0.01) reduced clonic phase compared to vehicle control. Curcumin in 100 mg/kg dose significantly (P < 0.001) inhibited PTZ induced seizure. Addition of curcumin to sub therapeutic dose of sodium valproate showed synergistic effect. Curcumin did not show any effect on memory retention. Inhibition of PTZ induced seizure by curcumin could be due to effect on γ-amino butyric acid receptor (GABA) pathway and its antioxidant property. Curcumin can be effective in absence seizure alone and as add on with sodium valproate
Keywords
- antiepileptic
- bcm
- BCM-95
- bcm95
- cognitivce
- curcugreen
- Curcumin
- momeory
- turmeric
- turmeric extract
Request More Information
Increase your business growth potential with our patented extracts
Let’s collaborate to refine your ideas or built from scratch
Arjuna Natural
Arjuna Natural is India’s leading manufacturer and exporter of standardized botanical extracts for pharmaceutical and nutraceutical industries for more than two decades. Established in 1989, the company has grown...Read More
