BCM-95® (CURCUGREEN®), 07 Aug 2021

Role of turmeric extract in minimising mucositis in patients receiving radiotherapy for head and neck squamous cell cancer: a randomised, placebo-controlled trial


P Arun, A Sagayaraj, S M Azeem Mohiyuddin and D Santosh

doi: 10.1017/S0022215120000316

Objective. To determine the role of turmeric extract in reducing mucositis in patients undergoing radiotherapy for head and neck cancer.

Methods. Sixty-one patients who underwent radiotherapy were included in the study and randomised into groups A and B. Patients in group A received 500 mg of turmeric extract (BCM-95) thrice daily, while patients in group B received placebo until radiotherapy completion. All patients were assessed for oral mucositis on a weekly basis during treatment and two months
post-treatment using the National Cancer Institute Common Terminology Criteria for Adverse Events and World Health Organization criteria.

Results. Both groups had a similar grade of mucositis in first two weeks of treatment. The severity of mucositis was progressive in the control group, with four patients developing grade 3 mucositis by week four. In group A, however, the majority of patients (73.3 per cent) had grade 1 mucositis after four weeks of treatment. The difference was statistically significant from the third week onwards ( p < 0.001).

Conclusion. Turmeric extract reduces the incidence and severity of radiation-induced mucositis, which can benefit patients undergoing radiation for head and neck cancer.

(https://doi.org/10.1017/S0022215120000316)


Keywords

  • Turmeric; Mucositis; Head And Neck Squamous Cell Carcinoma; Radiation; Chemoradiotherapy

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