BCM-95® (CURCUGREEN®), 06 Aug 2021

The Feasibility and Efficacy of a Brief Integrative Treatment for Adults With Depression and/or Anxiety: A Randomized Controlled Trial

Adrian L. Lopresti, PhD, Stephen J. Smith, MA, Alexandra P. Metse, PhD, Tiffany Foster, MA, and Peter D. Drummond, PhD

DOI: 10.1177/2515690X20937997

Introduction: The aim of this study was to investigate the efficacy and suitability of a brief integrative intervention, Personalized Integrative Therapy (PI Therapy), for the treatment of adult depression and/or anxiety.

Method: In this 6-week, 3-arm, parallel-group, randomized trial, PI Therapy delivered alone or with nutritional supplements (PI Therapy þ Supps) was compared to cognitive behaviour therapy (CBT) in 48 adults with depression and/or anxiety. All treatments were delivered as a 1-day workshop plus 6 weeks of reminder phone text messages to reinforce topics and skills covered in the workshop.

Result: Affective symptoms decreased significantly and to the same extent in all 3 conditions. At the end of treatment, 33% to 58% of participants reported levels of depressive symptoms in the normal range, and 50% to 58% reported nonclinical levels of anxiety. Compared to CBT and PI Therapy, PI Therapy þ Supps was associated with significantly greater improvements in sleep quality.

Conclusion: These findings suggest that a brief integrative intervention with or without supplements was comparable to CBT in reducing affective symptoms in adults with depression and/or anxiety. However, sleep quality improved only in the PI Therapy þ Supps condition. These findings will require replication with a larger cohort.



  • anxiety
  • clinical trial
  • depression
  • exercise
  • holistic
  • integrative treatment
  • nutrition

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