Research

All backed up by clinical studies and research.

We have been Leading the manufacturing of standardised Botanical extracts in-house scientifically & sustainably since 30 years.

Let’s talk

Published on 24 Nov 2021

Verapamil/Curcumin treatment attenuates the behavioral alterations observed in Williams Syndrome mice by regulation of MAPK pathway and Microglia overexpression.


Paula Ortiz-Romero, Gustavo Egea, Luis A Pérez-Jurado, Victoria Campuzano

The study investigated the progression of behavioral deficits present in CD (complete deletion) mice, a rodent model of Williams-Beuren syndrome (WBS), a rare neurodevelopmental disorder without any effective treatments.  The test compounds curcumin, verapamil and a combination of both were given as chronic treatments. These compounds have been proven to have beneficial effects over different cognitive aspects of various murine models and thus, may have neuroprotective effects in WBS. Treatment was administered orally dissolved in drinking water. A set of behavioral tests demonstrated the efficiency of combinatorial treatment. Some histological and molecular analyses were performed to analyze the effects of treatment and its underlying mechanism in CD mice. Behavioral improvement correlates with the molecular recovery of several affected pathways regarding MAPK signaling, in tight relation with the control of synaptic transmission. Moreover, CD mice showed an increased activated microglia density in different brain regions, which was prevented by treatment. Therefore, results show that treatment prevented behavioral deficits by recovering altered gene expression in cortex of CD mice, reducing activated microglia and normalizing Bdnf expression levels. These findings unravel the mechanisms underlying the beneficial effects of this novel treatment on behavioral deficits observed in CD mice, and suggest that the combination of curcumin and verapamil could be a potential candidate to treat the cognitive impairments in WBS patients. [Paula Ortiz-Romero, Gustavo Egea1, Luis A Pérez-Jurado, Victoria Campuzano. Verapamil/Curcumin treatment attenuates the behavioral alterations observed in Williams Syndrome mice by regulation of MAPK pathway and Microglia overexpression.

doi: 10.1101/2021.02.01.429086

Related reading

The Feasibility and Efficacy of a Brief Integrative Treatment for Adults With Depression and/or Anxiety: A Randomized Controlled Trial

| 24, Nov 2021 | read

Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model

| 24, Nov 2021 | read


Keywords

  • curcugreen
  • Curcuma longa; Curcumin; anticancer; antioxidant; bioavailability; biocurcumax.
  • Curcumin
  • study.no.70

Latest from Industry

Get inspired by the new reads

The Feasibility and Efficacy of a Brief Integrative Treatment for Adults With Depression and/or Anxiety: A Randomized Controlled Trial

Adrian L. Lopresti, PhD, Stephen J. Smith, MA, Alexandra P. Metse, PhD, Tiffany Foster, MA, and Peter D. Drummond, PhD The aim of this study was to investigate the efficacy and suitability of a brief integrative intervention, Personalized Integrative Therapy (PI Therapy), for the treatment of adult depression and/or anxiety. In this 6-week, 3-arm, parallel-group, ...Read More

| Published on 24, Nov 2021

Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model

Linda Saxe Einbond, Jing Zhou, Hsan-au Wu, Emeka Mbazor, Guiyun Song, Michael Balick, James A. DeVoti, Stephen Redenti and Mario R. Castellanos BackgroundThe phytochemical mixture TriCurin (curcumin, epigallocatechin gallate (EGCG) and resveratrol) eliminates human papillomavirus (HPV) (+) cancer cells in vitro and in vivo. In this study, we further evaluate TriCurin. MethodsThe activity of TriCurin ...Read More

| Published on 24, Nov 2021

Synofit Premium in Refractory Low Back Pain: A Retrospective Observational Study

Jiangan Qu1, Christian Mélot, Thierry Appelboom In this retrospective observational study, information about pain and quality of life was collected for analysis from medical records of 85 patients with chronic low back pain who were treated for 3 months with Synofit® Premium (2 – 3 capsules daily), a liquid mixture of green-lipped mussel from New ...Read More

| Published on 24, Nov 2021

We are always supporting our network of practitioners

Subscribe to our premium service for people like you who are passionate for science and want to know more about nature and its phenomena. Get detailed reports, methods and many more.

Increase your business growth potential with our patented extracts

Let’s collaborate to refine your ideas or built from scratch

Arjuna Natural

Arjuna Natural Ltd is India’s leading manufacturer and exporter of standardized botanical extracts for pharmaceutical and nutraceutical industries for more than two decades. Established in 1989, the company has grown...Read More

Get all the Updates about us!

For sales enquiries please email us at
sales@arjunanatural.com