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Published on 16 Jan 2024

Effectiveness of Giving Biocurpain to Improve Functional Status in Osteoarthritis Patients


Background: Osteoarthritis (OA) is a progressive arthritis that decreases quality of life. This disease can not be cured and is limited and can only reduce pain experienced by patients. The drug that is often used is non-steroidal anti-inflammatory drugs (NSAIDs), these medicines can not be separated from side effects if used in the long term. An effective and safe drug is needed to improve functional status in osteoarthritis paitents.

Objective: Rizaldy Taslim Pinzon1 *, Eric2 To compared the effectiveness of biocurpain which has a marketing authorization number TR172599281 with NSAIDs to improves functional Status in the treatment of OA patients. Methods: A Randomized Control Trial (RCT) involving OA patients. The treatment used were Biocurpain (Curcuma longa 350 mg and Boswellia serrata 150 mg) and NSAIDs (Ibuprofen 400 mg). Subjects were randomized into 2 groups (Group 1 received Biocurpain and group 2 recieved NSAIDs). Functional status measurement using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).

Results: There were 67 subjects that participated in this study, 5 subjects were lost to follow-up and 3 subjects could not continue the study due to side
effects. 59 subjects completed the trial (group 1: 29 subjects and group 2: 30 subjects). There were no significant differences between groups in improving functional status (p: 0.771), the use of rescue medication (p: 0.370), the incidence of adverse events at visit II (p: 0.215) and visit III (p: 0.537) on OA subjects. Group 2 showed more subjects experiencing side effects.
Conclusion: Biocurpain as effective as NSAIDs to improve functional status in OA patients.

Indonesian Journal of Pharmacy and Pharmaceutical Sciences Vol. 7 No. July 1, 2020 57

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Arjuna Natural is India’s leading manufacturer and exporter of standardized botanical extracts for pharmaceutical and nutraceutical industries for more than two decades. Established in 1989, the company has grown...Read More

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