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Verapamil/Curcumin treatment attenuates the behavioral alterations observed in Williams Syndrome mice by regulation of MAPK pathway and Microglia overexpression.
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Paula Ortiz-Romero, Gustavo Egea, Luis A Pérez-Jurado, Victoria Campuzano The study investigated the progression of behavioral deficits present in CD (complete deletion) mice, a rodent model of Williams-Beuren syndrome (WBS), a rare neurodevelopmental disorder without any effective treatments. The test compounds curcumin, verapamil and a combination of both were given as chronic treatments. These compounds have ... Read full Research
The benefit of Curcuma longa and Boswellia serrata to improve quality of life in osteoarthritis patients: a randomized controlled trial.
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Background: Quality of life (QoL) can be affected by chronic pain in osteoarthritis (OA). Previous studies showed that combination of Curcuma longa (CL) and Boswellia serrata (BS) extract (CB extract) are promising foralternative treatment for pain in OA. This study aimed to measure the benefit of CB extract to improve QoL in patients with OA. ... Read full Research
Red Spinach Extract Increases Ventilatory Threshold during Graded Exercise Testing
Deepak | Article
Background: We examined the acute effect of a red spinach extract (RSE) (1000 mg dose; ~90 mg nitrate (NO 3 – )) on performance markers during graded exercise testing (GXT). Methods: For this randomized, double-blind, placebo (PBO)-controlled, crossover study, 15 recreationally-active participants (aged 23.1 ± 3.3 years; BMI: 27.2 ± 3.7 kg/m²) reported >2 h post-prandial and ... Read full Research
A-90 Day Gavage Safety Assessment of Boswellia serrata in Rats
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Abstract. The present study deals with the evaluation and assessment of the safety/toxic potential of Boswellia serrata, a well known Ayurvedic herb used to treat disorders of the digestive system, respiratory ailments and bone-related diseases. A repeated dose oral (90 days) toxicity study of Boswellia serrata was carried out. For this, 10 rats of each sex were treated ... Read full Research
Fast Relief of Acute Musculoskeletal Pain in Different Body Parts Following Exercise – A Randomized Double-Blind Placebo-Controlled Human Study with Curcuma longa and Boswellia serrata Extracts
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DOI: 10.36347/sjams.2022.v10i03.008 Meghana Murthy, Girish H. Rudrappa, Sanjeev Kumar Kare, Santosh Saklecha, Indraneel Basu, Ajay Gupta Acute pain in different parts of the body viz., head and neck, trunk, upper and lower limbs tend to be perceived differently. A randomized double-blinded placebo-controlled study was conducted on 232 healthy participants with acute musculoskeletal pain. The participants ... Read full Research
Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen
Deepak | Article
Background: Acetaminophen (paracetamol) is one of the most commonly used over-the-counter for pain relief. Management of acute pain with plant-based nutrients has remained suboptimal due to an absence of data supporting acute relief of pain. In the present study, it was hypothesized that high-dissolution liquid treatment of black sesame extract oil, Curcuma longa and Boswellia serrata ... Read full Research
Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract
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A Randomized, Double-Blind, Placebo-Controlled Trial with an Open-Label Extension on Healthy Participants. Tharakan, A.; Shukla, H.; Benny, I.R.; Tharakan, M.; George, L.; Koshy, S. DOI: 10.3390/jcm10163644 Abstract: The immunomodulatory effect of Withania somnifera (WS) extract was tested in healthy adults. In this randomized placebo-controlled double-blinded study, subjects were allocated either 60 mg WS extract or ... Read full Research
A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults
Deepak | Article
DOI: 10.1177/1557988319835985 Adrian L. Lopresti, Peter D. Drummond, and Stephen J. Smith Objective: Non-restorative sleep (NRS) affects 10% people worldwide, leading to poor sleep quality, as well as physical and cognitive fatigue. This is the first human study in which an extract of ashwagandha (Withania somnifera Dunal L.) was evaluated for effects in improving overall sleep ... Read full Research
Acute and sub chronic toxicity studies of purified withania somnifera extract in rats.
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International Journal of Pharmacy and Pharmaceutical Sciences, Vol 10, Issue 12, 2018 Benny Antony, Merina Benny, Binu T Kuruvilla, Nishant Kumar Gupta, Anu Sebastian, Sherina Jacob DOI: 10.22159/ijpps.2018v10i12.29493 Objective: The objective of the present study was to evaluate the acute and sub-chronic (90 d; repeated dose) toxicity of Withania somnifera (ashwagandha) extract in rats. Methods: ... Read full Research
Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withania somnifera) extract on nonrestorative sleep
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Abhijit Deshpande, MD, Nushafreen Irani, MSc, Rathna Balakrishnan, MD Abstract: Nonrestorative sleep (NRS) is one of the cardinal symptoms of insomnia and can occur independent of other components of insomnia. Among the sleep disturbances, NRS has been little studied in the general population, even though this symptom plays an important role in several medical conditions ... Read full Research
AmlamaxTM in the management of dyslipidemia in humans
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Background: Hypercholesterolemia is the major cause of cardiovascular diseases leading to myocardial infarctions leading to considerable morbidity and mortality. During the past decade a group of molecules referred to as statins such as simvastatin, atrovastatin have been tried with great success in reducing total cholesterol. These molecules act by inhibiting the HMG CoA reductase enzyme ... Read full Research
Verapamil/Curcumin treatment attenuates the behavioral alterations observed in Williams Syndrome mice by regulation of MAPK pathway and Microglia overexpression.
connect arjuna | Article
Paula Ortiz-Romero, Gustavo Egea, Luis A Pérez-Jurado, Victoria Campuzano The study investigated the progression of behavioral deficits present in CD (complete deletion) mice, a rodent model of Williams-Beuren syndrome (WBS), a rare neurodevelopmental disorder without any effective treatments. The test compounds curcumin, verapamil and a combination of both were given as chronic treatments. These compounds have ... Read full Research
The benefit of Curcuma longa and Boswellia serrata to improve quality of life in osteoarthritis patients: a randomized controlled trial.
connect arjuna | Article
Background: Quality of life (QoL) can be affected by chronic pain in osteoarthritis (OA). Previous studies showed that combination of Curcuma longa (CL) and Boswellia serrata (BS) extract (CB extract) are promising foralternative treatment for pain in OA. This study aimed to measure the benefit of CB extract to improve QoL in patients with OA. ... Read full Research
A Randomized Controlled Trial of Curcuma Longa and Boswellia Serrata Extract in Osteoarthritis.
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Rizaldy Taslim Pinzon, Rosa De Lima Renita Sanyasi, Esdras Ardi Pramudita& Septian Dewi Periska Chronic pain is the major complaint in subjects with osteoarthritis (OA). Non- steroid anti inflammatory drug (NSAID) is still the drug of choice in Indonesia to treat OA patients. The prolonged consumption of NSAID may lead to many adverse events (AE). ... Read full Research
Potential Therapeutic Effects of Curcuma longa extract in Patients with Osteoarthritis: A Randomized Controlled Trial.
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[Rizaldy Taslim Pinzon, Fransiscus Buwana; Potential Therapeutic Effects of Curcuma longa extract in Patients with Osteoarthritis: A Randomized Controlled Trial; J. Pharm. Sci. & Res. Vol. 11(11), 2019, 3628-3633] Osteoarthritis (OA) is the most common degenerative joint disorder in the elderly and a major public health problem in worldwide. Non-steroidal anti-inflammatory drug (NSAID) is a ... Read full Research
Antidiabetic effect of bio-enhanced preparation of turmeric in streptozotocin-nicotinamide induced type 2 diabetic Wistar rats.
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[Vinay Kumar Sayeli, Ashok K. Shenoy; doi.org/10.1016/j.jaim.2021.04.010] Poor oral bioavailability of curcumin, the active ingredient in turmeric, has limited its therapeutic use in various diseases including diabetes mellitus (DM). The present study was aimed at evaluating and comparing the antidiabetic activity as well as pharmacokinetic profile of two turmeric extracts. Rats were divided into seven ... Read full Research
Curcuma longa and Boswellia Serrata for improving functional status in osteoarthritis patients: From bench to bedside evidences.
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[Rizaldy Taslim Pinzon, Vincent Ongko Wijaya; DOI: 10.3126/ajms.v10i5.24918] The management of osteoarthritis (OA) represents a real challenge. Curcumin is a highly pleiotropic molecule with an excellent safety profile. Some previous studies showed the extract of Curcuma longa and Boswellia Serrata(CB extract) is a promising potential as therapeutic interventions against OA. This study aimed to measure ... Read full Research
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Arjuna Natural
Arjuna Natural is India’s leading manufacturer and exporter of standardized botanical extracts for pharmaceutical and nutraceutical industries for more than two decades. Established in 1989, the company has grown...Read More
