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Rhuleave-K®: A Natural solution in pain relief
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Rhuleave-K®: A Natural solution in pain relief

Article Published in P&C Magazine Rhuleave-K® by Arjuna Natural Pvt. Ltd. represents a significant advancement in natural pain relief. Combining the potent anti-inflammatory and pain-relieving properties of Curcuma longa (Curcumin) and Boswellia serrata, this innovative product utilizes patented SPEEDTECH® technology for rapid and effective pain management. Rhuleave-K® is clinically proven to deliver fast relief comparable to conventional painkillers like Acetaminophen but without the common side effects, offering a safe and holistic alternative for managing both menstrual and musculoskeletal pain. SPEEDTECH® Technology The patented SPEEDTECH® technology ensures that each component in Rhuleave-K® is evenly dispersed, maintaining potency and delivering quick action. This technology creates a unique matrix that provides consistent and reliable pain relief, making it a standout in the realm of natural pain management solutions. Holistic Effects Rhuleave-K®’s holistic approach to pain relief addresses not only the symptoms but also supports overall well-being. Unlike many conventional pain relievers, it is free from side effects that can affect the stomach, heart, liver, and kidneys. Its safety is well-documented even at high dosages, making it a trustworthy choice for those seeking a natural alternative to manage pain. Clinically Proven Efficacy Clinical studies have demonstrated that Rhuleave-K® provides immediate and significant pain relief, comparable to Acetaminophen. For example, a 2020 study involving 88 subjects with acute musculoskeletal pain showed notable reductions in pain intensity within just six hours of taking Rhuleave-K®. Another study in 2022 involving 232 participants highlighted its effectiveness across various types of pain, including head, neck, and limb pain. In both cases, Rhuleave-K® delivered faster relief than the placebo, beginning as early as 40 minutes after consumption. Empowering Women’s Health For women experiencing primary dysmenorrhea, Rhuleave-K® offers a natural and effective solution to alleviate menstrual discomfort. A study published in the Journal of Clinical Medicine in 2023 confirmed Rhuleave-K®’s efficacy in managing menstrual pain, providing 12.6 times better relief than a placebo. About Arjuna Natural Pvt. Ltd. With more than three decades of experience, Arjuna Natural is a leader in natural extracts for health and sustainable living. The company is committed to innovation, quality, and scientific research, ensuring that products like Rhuleave-K® meet the highest global standards. Arjuna Natural’s facilities are GMP-certified and hold multiple certifications, reflecting their dedication to excellence in natural health solutions.

Nature’s Power for Fast Pain Relief
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Nature’s Power for Fast Pain Relief

A testament to this is Rhuleave-K®, which uses herbs like Curcuma longa and Boswellia serrata along with other natural ingredients to deliver rapid pain relief and reduce inflammation. This ground-breaking matrix, expertly formulated with patented SPEEDTECH® technology, guarantees that every ingredient maintains its potency and is dispersed evenly for optimal results.  https://nutrifycsuite.com/pdf/JulyNutrition Insight2024-Newsletter.pdf The SPEEDTECH® Science  This innovative technology creates a powerful combination of natural ingredients, ensuring accurate filled weight and faster action. The unique matrix formula employed by SPEEDTECH® allows for uniform distribution of its components, delivering quick and reliable pain relief.  Holistic Effects  One of Rhuleave-K®’s standout features is its holistic approach to pain relief. Unlike many conventional pain relievers, Rhuleave-K® is free from side effects that commonly affect the stomach, heart, liver, and kidneys. Its safety is proven even at high dosages, making it a trustworthy choice for those seeking a natural alternative to manage pain. Additionally, Rhuleave-K® boasts synergistic antioxidant activity, further supporting overall health and well-being.  Clinically Proven Efficacy  Clinical data demonstrates that this formula provides fast pain relief comparable to Acetaminophen (Paracetamol). In a randomized, active-controlled, open-label study published in 2020, 88 healthy subjects experiencing acute musculoskeletal pain due to exercise were given either Rhuleave-K® (1,000mg/d) or Acetaminophen (1,000mg/d) over seven days. Results showed significant reductions in pain intensity and relief within the first six hours, as well as at three and seven days. Measurements included perceptible and meaningful pain relief, the McGill Pain Questionnaire, and the Patient Global Impression Change.  The Natural Choice for Pain Relief  Rhuleave-K®’s formula, rooted in centuries of traditional use of its components as food or medicine, stands out for its safety and effectiveness. Whether dealing with occasional muscle pain, inflammation due to exercise, or overuse, Rhuleave-K® offers a natural, fast-acting solution. By leveraging the potent bioactive from turmeric, Boswellia, and other ingredients, Rhuleave-K® provides Fast relief, proving that the best solutions often come from nature itself.  About Arjuna Natural Pvt, Ltd.  For more than three decades, Arjuna Natural has been an innovative, science-based organization specializing in natural extracts for Health and sustainable living. The company always sought to serve the unmet needs by bettering lives across the globe through innovative natural solutions. Established in 1992, the company has grown rapidly, with customers in more than 65 countries, and has an advanced research facility that works in collaboration with international universities on phytochemistry, pharmacokinetics, formulation, development, pre-clinical, and toxicity studies. Arjuna Natural’s facilities comply with the highest world standards, are GMP-certified, and have ISO, NSF, and halal and Star-K kosher certification.  Authored by  Dr. Benny Antony  | Joint Managing Director  

Golden Standard Curcumin Extract
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Golden Standard Curcumin Extract

News provided by EIN Presswire Sep 25, 2024,  For over two decades, BCM-95, developed by Arjuna Natural, has set the global benchmark for curcumin extracts, renowned for its superior bioavailability and 100% turmeric formulation. Combining curcuminoids with turmeric essential oils, BCM-95 enhances absorption naturally, supported by 90 scientific publications and 42 patents. Trusted by healthcare professionals across 74 countries, BCM-95 continues to lead the market, providing proven benefits for joint, brain, and overall health. With patents valid until 2028, BCM-95 remains the industry’s top choice for quality and innovation. BCM-95: The gold standard in Curcumin extracts continues to lead

Dr.Benny Antony ‘s comment on Nutrition Insight
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Dr.Benny Antony ‘s comment on Nutrition Insight

30 Aug 2024 — As European food authorities highlight potential health issues associated with ashwagandha (Withania somnifera), the nutrition industry underscores the ingredient’s safety, supported by research data. At the same time, companies highlight how the increased scrutiny helps drive higher safety and quality standards. They call on stakeholders and manufacturers to submit robust and comprehensive safety data to authorities. The ingredient, used in traditional remedies for thousands of years, has been banned in Denmark after a risk assessment concluded that it could not set a daily intake limit under which there would be no risk of harmful effects. Earlier this year, the Netherlands and France advised certain population groups against using the botanical.  In this last article of our three-part series on ashwagandha, Nutrition Insight discusses the market impact of the increased scrutiny of the botanical with key market players Arjuna Natural and Sabinsa. In earlier installments, we examined food safety authorities’ evaluations and discussed the available data on the botanical’s potential health risks with botanical experts. “The recent ban on ashwagandha by authorities in countries like Denmark seems to contradict the extensive scientific and traditional evidence supporting its safety and benefits,” says Dr. Benny Antony, joint managing director at Arjuna Natural. Ref: https://www.nutritioninsight.com/news/unjustified-ban-industry-responds-to-ongoing-scrutiny-of-ashwagandha-safety.html

Unlocking the Power of Ashwagandha: Cognitive and Eye Health Benefits
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Unlocking the Power of Ashwagandha: Cognitive and Eye Health Benefits

Ashwagandha, a revered herb in Ayurvedic medicine, has been used for centuries to promoteoverall health and well-being. Ashwagandha properties like adaptogenic behaviour,ashwagandha is gaining popularity for its potential benefits in cognitive and eye health. Thisblog explores the various ways ashwagandha extract can enhance brain function and vision,supported by scientific research and traditional wisdom. What is Ashwagandha? Ashwagandha (Withania somnifera), also known as Indian ginseng or winter cherry, is a smallshrub native to India and Southeast Asia. The roots and leaves of the plant are used to makeashwagandha extract, which is rich in bioactive compounds like withanolides. Thesecompounds are responsible for the herb’s therapeutic effects. How Does Ashwagandha Work? Ashwagandha works by modulating the body’s stress response and enhancing its resilience tostressors. It acts on the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol levels andpromoting a sense of calm. Additionally, ashwagandha properties of an antioxidant help protectcells from oxidative damage, which is crucial for maintaining cognitive and eye health. The herbalso influences neurotransmitter activity, which can improve mood and cognitive function. Bybalancing the body’s systems, ashwagandha supports overall health and well-being. Ashwagandha for Brain Health Improves Memory and Cognitive Function: Ashwagandha extract benefits cognitive function byenhancing memory, attention, and information processing speed. Studies have shown thatregular consumption of ashwagandha can improve both immediate and general memory inpeople with mild cognitive impairment. This makes it a valuable supplement for students,professionals, and the elderly. Reduces Stress and Anxiety: One of the key ashwagandha properties is its ability to reducestress and anxiety. By lowering cortisol levels, ashwagandha helps in managing stress, which inturn supports better cognitive function. This is particularly beneficial in today’s fast-paced world,where stress is a common issue. Neuroprotective Effects: Neuroprotective ashwagandha properties help in protecting brain cellsfrom damage. This is particularly beneficial in preventing neurodegenerative diseases likeAlzheimer’s and Parkinson’s. The herb’s ability to enhance brain function and protect againstcognitive decline makes it a powerful tool for maintaining mental health. Ashwagandha for Better Vision Reduces Eye Strain: Ashwagandha extract can help reduce eye strain caused by prolongedscreen time. Anti-inflammatory ashwagandha properties soothe the eyes and reduce discomfort. This is especially useful for individuals who spend long hours in front of computers or digitaldevices. Improves Night Vision: The antioxidants in ashwagandha, particularly withanolides, help inimproving night vision by protecting the retina from oxidative stress. This can be beneficial forpeople who drive at night or have difficulty seeing in low light conditions. Prevents Age-Related Eye Disorders: Regular use of ashwagandha can help in preventing age-related eye disorders such as cataracts and macular degeneration by reducing oxidativedamage. By protecting the eyes from damage, ashwagandha supports long-term eye health. How to Use Ashwagandha Powder Dosage: Typically, 300-500 mg of ashwagandha extract is recommended daily. However, it’sbest to consult with a healthcare provider for personalized advice. Forms: Ashwagandha is available in various forms, including powder, capsules, and liquidextracts. Choose the form that best suits your needs. Consumption: Mix ashwagandha powder with warm milk or water, or add it to smoothies andteas for easy consumption. You can also incorporate it into recipes like soups and stews foradded health benefits. Risks and Warnings of Ashwagandha Pregnancy and Breastfeeding: Pregnant and breastfeeding women should avoid ashwagandhadue to potential risks. Autoimmune Diseases: Individuals with autoimmune diseases should consult a doctor beforeusing ashwagandha, as it may stimulate the immune system. Medication Interactions: Ashwagandha may interact with certain medications, such asimmunosuppressants and sedatives. Always consult a healthcare provider before starting anynew supplement. How Much Ashwagandha Should You Take? The recommended dosage of ashwagandha varies depending on the form and purpose of use.For general health benefits, 300-500 mg of standardized ashwagandha extract per day iscommonly suggested. For specific conditions, higher doses may be recommended undermedical supervision. It’s important to start with a lower dose and gradually increase it to assesstolerance and effectiveness. Possible Side Effects of Ashwagandha Digestive Issues: Some people may experience digestive issues like diarrhea, nausea, andstomach upset. Drowsiness: Ashwagandha can cause drowsiness in some individuals, especially when taken inhigher doses. Allergic Reactions: Rarely, some individuals may experience allergic reactions such as skinrashes and itching. Ashwagandha and Other Supplements: What to Know Combining ashwagandha with other supplements can enhance its benefits. For example,pairing it with omega-3 fatty acids can support brain health, while combining it with antioxidantslike vitamin C can boost its protective effects on the eyes. However, it’s essential to consult witha healthcare provider before combining supplements to avoid potential interactions.Understanding how different supplements work together can help you create a more effectivehealth regimen. Choosing the Right Ashwagandha Supplement When selecting an ashwagandha supplement, consider the following:1) Standardization: Look for supplements standardized to contain a specific percentage ofwithanolides, the active compounds in ashwagandha. 2) Reputable Brands: Choose products from reputable ashwagandha extractmanufacturers in India, such as KSM-66 and Shoden ashwagandha extract, known fortheir quality and efficacy. 3) Form: Decide whether you prefer powder, capsules, or liquid extracts based on yourconvenience and preference. Reading reviews and checking for third-party testing canalso help ensure you choose a high-quality product. Conclusion Ashwagandha is a powerful herb with numerous benefits for cognitive and eye health. Itsadaptogenic and antioxidant properties make it an excellent supplement for enhancing memory,reducing stress, and protecting vision. By choosing high-quality ashwagandha extract fromreputable manufacturers in India, you can harness the full potential of this ancient herb tosupport your overall well-being. Whether you’re looking to boost brain function, improve vision,or simply enhance your overall health, ashwagandha offers a natural and effective solution.

From Restless Nights to Restful Slumber: How Turmeric Oil Can Transform Your Sleep
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From Restless Nights to Restful Slumber: How Turmeric Oil Can Transform Your Sleep

Introduction In today’s fast-paced world, restless nights have gotten to be a common issue for numerous people. The journey for a great night’s rest regularly leads individuals to investigate different cures, from conventional herbs to present day pharmaceuticals. One such common cure picking up consideration  is turmeric oil. Known for its benefits, turmeric oil, wealthy in turmeric curcumin, offers a promising arrangement for those battling with sleep issues. This article dives into how turmeric oil can help rest, giving a characteristic and viable elective to ordinary rest aids. The Sleep-Enhancing Power of Turmeric Oil Turmeric oil, determined from the turmeric root, is pressed with curcumin extricate, an effective compound known for its anti-inflammatory and antioxidant properties. Curcumin producers in India have been tackling these benefits for centuries, and recent studies have highlighted its potential in advancing better sleep. The sleep-enhancing control of turmeric oil lies in its capacity to address several variables that contribute to sleep disturbances. Soothing Inflammation for Better Rest Inflammation is a common offender behind numerous issues, including sleep disorders. Turmeric oil, with its high concentration of curcumin 95, helps soothe inflammation in the body. By decreasing irritation, turmeric oil can ease inconvenience and pain, making it easier for people to fall asleep and remain asleep all through the night. Enhancing Serotonin and Melatonin Production Serotonin and melatonin are pivotal hormones that direct rest. Serotonin helps to  stabilise mood and feelings of well-being, while melatonin controls the sleep-wake cycle. Turmeric oil has been found to enhance the production of these hormones, thanks to its active ingredient, bcm 95 curcumin. By boosting serotonin and melatonin levels, turmeric oil can help improve sleep quality and duration. Alleviating Stress and Anxiety for Peaceful Sleep Stress and anxiety are significant barriers to achieving restful sleep. Turmeric oil’s calming properties can help alleviate these issues. The curcumin extract in turmeric oil has been shown to reduce stress and anxiety levels, promoting a sense of calm and relaxation. This, in turn, makes it easier to drift into a peaceful slumber. Regulating Your Natural Sleep-Wake Cycle A disrupted sleep-wake cycle can lead to insomnia and other sleep disorders. Turmeric oil can help regulate this cycle by supporting the body’s natural rhythms. By enhancing melatonin production and reducing stress, turmeric oil helps synchronize the sleep-wake cycle, ensuring a more consistent and restful sleep pattern. Unlocking Turmeric Oil’s Sleep Benefits Beyond Supplements While turmeric supplements are popular, turmeric oil offers additional benefits through various applications. Incorporating turmeric oil into your daily routine can provide a holistic approach to improving sleep. Aromatherapy with Turmeric Oil: A Path to Deep Sleep Aromatherapy is a powerful method to harness the benefits of turmeric oil. Adding a few drops of turmeric oil to a diffuser can create a calming atmosphere, promoting relaxation and preparing the body for sleep. The soothing aroma of turmeric oil can help reduce stress and anxiety, making it easier to fall asleep. Relaxing Turmeric Oil Bath: Your Recipe for Restful Nights A warm bath infused with turmeric oil can be a luxurious way to unwind before bed. The combination of warm water and the anti-inflammatory properties of turmeric curcumin can relax muscles and soothe the mind. To prepare a relaxing turmeric oil bath, add a few drops of turmeric oil to your bathwater and soak for 20-30 minutes. This ritual can help ease tension and promote a restful night’s sleep. Golden Elixir for Tranquil Sleep Turmeric oil can also be consumed as a golden elixir. Mixing a few drops of turmeric oil with warm milk or herbal tea can create a soothing bedtime drink. This golden elixir not only provides the sleep-enhancing benefits of turmeric curcumin but also offers a comforting and relaxing way to end the day. Natural Sleep Support: A Safer Alternative to Traditional Aids Many traditional sleep aids come with side effects and the risk of dependency. Turmeric oil, on the other hand, offers a natural and safer alternative. Its ability to address multiple factors that affect sleep makes it an effective solution without the drawbacks associated with conventional sleep medications. Choose the Best Source for Premium Turmeric Oil To reap the full benefits of turmeric oil, it’s essential to choose a high-quality product. Look for turmeric oil from reputable curcumin manufacturers in India, known for their expertise in producing pure and potent curcumin extract. Ensure that the product contains a high concentration of curcumin 95 or bcm 95 curcumin for maximum efficacy. Conclusion Turmeric oil is a versatile and powerful natural remedy that can transform sleepless nights into restful slumber. By addressing inflammation, enhancing hormone production, alleviating stress, and regulating the sleep-wake cycle, turmeric oil offers a comprehensive solution for sleep issues. Incorporating turmeric oil into your routine through aromatherapy, baths, or as a golden elixir can provide a holistic approach to better sleep. As a natural sleep support, turmeric oil stands out as a safer and effective alternative to traditional sleep aids. Choose premium turmeric oil from trusted sources to ensure you receive the highest quality and potency for optimal sleep benefits.

Debunking Myths: The Truth About Curcuma Longa Extract
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Debunking Myths: The Truth About Curcuma Longa Extract

Curcuma longa, commonly known as turmeric, has been celebrated for centuries for its medicinal properties. The active compound in turmeric, curcumin, is responsible for many of its health benefits. However, with its rising popularity, several myths have emerged about curcuma longa extract. This blog aims to separate fact from fiction, providing a clear understanding of its true benefits and limitations. We’ll explore the myths and facts surrounding curcuma longa extract, focusing on its therapeutic potential, absorption, and safety, and highlighting the role of curcumin manufacturers in India in producing high-quality curcumin extracts. Myth #1: Curcuma longa extract can cure various diseases Fact: While curcuma longa extract, particularly curcumin, has shown promise in managing and alleviating symptoms of various conditions, it is not a cure-all. Research indicates that curcumin has anti-inflammatory, antioxidant, and anticancer properties. It can help manage conditions like arthritis, inflammatory bowel disease, and cardiovascular issues. However, it should be viewed as a complementary therapy rather than a standalone cure. The efficacy of curcumin in treating diseases varies, and more extensive clinical trials are needed to establish its role in disease management. Curcumin extracts are widely studied, and curcumin manufacturers in India have been at the forefront of producing high-quality curcumin products that are used worldwide. These manufacturers focus on creating turmeric curcumin supplements that meet international standards, ensuring that consumers receive the best possible products. However, it is essential to remember that while these supplements can support health, they are not a substitute for professional medical treatment. Myth #2: Curcuma longa extract is easily absorbed by the body Fact: One of the significant challenges with curcumin is its poor bioavailability. Curcumin is not easily absorbed by the body, which limits its effectiveness. To enhance absorption, curcumin is often combined with piperine, a compound found in black pepper, which can increase its bioavailability by 2000%. Additionally, formulations like BCM-95 curcumin have been developed to improve absorption and efficacy. Despite these advancements, it’s essential to understand that not all curcumin extracts are created equal, and choosing the right formulation is crucial for achieving the desired health benefits. BCM-95 curcumin is a specialized formulation that has gained popularity due to its enhanced absorption. Unlike standard turmeric curcumin products, BCM-95 curcumin combines curcuminoids with essential oils from turmeric, which helps improve bioavailability and effectiveness. This formulation is widely used by curcumin manufacturers in India and around the world to produce supplements that offer better therapeutic outcomes. Myth #3: Curcuma longa extract can be an alternative to medications Fact: While curcuma longa extract has numerous health benefits, it should not be considered a replacement for conventional medications. Curcumin can complement traditional treatments, particularly for conditions like arthritis and inflammation. However, it is not a substitute for prescribed medications. Patients should consult healthcare providers before making any changes to their treatment plans. Curcumin can interact with certain medications, and its use should be carefully monitored to avoid adverse effects. Curcumin manufacturers in India produce a wide range of curcumin extracts, catering to both domestic and international markets. These curcumin extracts are used in dietary supplements, functional foods, and even cosmetics. However, despite the widespread availability of turmeric curcumin products, it is crucial to recognize that they should be used as part of a broader healthcare strategy, not as a replacement for necessary medications. Myth #4: Curcuma longa extract has no harmful side effects Fact: Although curcuma longa extract is generally considered safe, it can cause side effects in some individuals. Common side effects include digestive issues like nausea and diarrhea. High doses of curcumin can also lead to liver problems and interact with medications such as blood thinners and diabetes drugs. It’s crucial to use curcumin supplements as directed and consult a healthcare provider, especially if you have underlying health conditions or are taking other medications. Conclusion Curcumin extracts produced by reputable curcumin manufacturers in India are subject to rigorous quality control measures to ensure safety and efficacy. However, even the highest quality turmeric curcumin supplements can cause side effects if not used properly. Consumers should be mindful of dosage recommendations and potential interactions with other medications. Curcuma longa extract, particularly curcumin, offers numerous health benefits, but it’s essential to approach its use with a clear understanding of its limitations and potential risks. While it can support the management of various health conditions, it is not a cure-all and should not replace conventional treatments. Enhancing its bioavailability through formulations like BCM-95 curcumin can improve its effectiveness, but users should be aware of possible side effects and interactions with other medications. Curcumin manufacturers in India play a vital role in producing high-quality curcumin extracts that are used worldwide. These manufacturers are constantly innovating to improve the safety and efficacy of turmeric curcumin products. By debunking these myths, we can better appreciate the true potential of curcuma longa extract and use it safely and effectively.

FOSTAC Training at CBE.
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FOSTAC Training at CBE.

FOSTAC Training at CBE Division. Cbe, Edayar & Livlong representatives participating. The Food Safety Training and Certification (FoSTaC) program, initiated by the Food Safety and Standards Authority of India (FSSAI) in July 2017, was implemented by Arjuna Natural in their Coimbatore division. This training and certification ecosystem for food businesses is designed to enhance awareness and understanding of food safety regulations and policies, promoting the highest standards of food safety and hygiene.

At IPPE 2024, USA
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At IPPE 2024, USA

Reflecting on the recently concluded International Production & Processing Expo (IPPE), where industry leaders, including Arjuna Natural, came together to drive business development, adopt best practices, streamline operations, and maintain a competitive edge. The event provided a unique platform for cultivating relationships, exploring new suppliers and vendors, and connecting with colleagues, all in one comprehensive gathering. This year, Arjuna Natural actively contributed to the diverse showcase of advancements in solutions, technologies, research, processes, services, and products within the global animal food and nutrition industries at IPPE in Atlanta, GA, USA. It was an invaluable opportunity to stay at the forefront of innovation and engage with industry experts.

Effectiveness of Giving Biocurpain to Improve Functional Status in Osteoarthritis Patients
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Effectiveness of Giving Biocurpain to Improve Functional Status in Osteoarthritis Patients

Background: Osteoarthritis (OA) is a progressive arthritis that decreases quality of life. This disease can not be cured and is limited and can only reduce pain experienced by patients. The drug that is often used is non-steroidal anti-inflammatory drugs (NSAIDs), these medicines can not be separated from side effects if used in the long term. An effective and safe drug is needed to improve functional status in osteoarthritis paitents. Objective: Rizaldy Taslim Pinzon1 *, Eric2 To compared the effectiveness of biocurpain which has a marketing authorization number TR172599281 with NSAIDs to improves functional Status in the treatment of OA patients. Methods: A Randomized Control Trial (RCT) involving OA patients. The treatment used were Biocurpain (Curcuma longa 350 mg and Boswellia serrata 150 mg) and NSAIDs (Ibuprofen 400 mg). Subjects were randomized into 2 groups (Group 1 received Biocurpain and group 2 recieved NSAIDs). Functional status measurement using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results: There were 67 subjects that participated in this study, 5 subjects were lost to follow-up and 3 subjects could not continue the study due to sideeffects. 59 subjects completed the trial (group 1: 29 subjects and group 2: 30 subjects). There were no significant differences between groups in improving functional status (p: 0.771), the use of rescue medication (p: 0.370), the incidence of adverse events at visit II (p: 0.215) and visit III (p: 0.537) on OA subjects. Group 2 showed more subjects experiencing side effects.Conclusion: Biocurpain as effective as NSAIDs to improve functional status in OA patients. Indonesian Journal of Pharmacy and Pharmaceutical Sciences Vol. 7 No. July 1, 2020 57

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